Abstract
The novel imidazo[4,5-c]pyridine 1,2,5-oxadiazol-3-yl template affords an excellent start point for identification of inhibitors of a number of protein kinases. Here we report on its optimisation for mitogen and stress-activated protein kinase-1 (MSK-1) inhibitory activity, and selectivity over other kinases.
MeSH terms
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Amines / chemical synthesis
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Amines / chemistry
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Amines / pharmacology*
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Imidazoles / chemical synthesis
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Imidazoles / chemistry
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Imidazoles / pharmacology*
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Molecular Structure
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Oxadiazoles / chemical synthesis
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Oxadiazoles / chemistry
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Oxadiazoles / pharmacology*
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Pyridines / chemical synthesis
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Pyridines / chemistry
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Pyridines / pharmacology*
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Ribosomal Protein S6 Kinases, 90-kDa / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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Amines
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Enzyme Inhibitors
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Imidazoles
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Oxadiazoles
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Pyridines
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Ribosomal Protein S6 Kinases, 90-kDa
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mitogen and stress-activated protein kinase 1